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US senators introduce bipartisan bill to create a NIH‑based foundation accelerating cardiovascular disease research

Executive summary: Senators Tillis and Padilla introduced a bipartisan bill (S.5469) to create the Heart Security Foundation, a federally chartered nonprofit that would operate under the NIH to accelerate cardiovascular research. Cardiovascular disease remains the top cause of death in the United States; the bill seeks to increase research funding and improve prevention and early detection through a public‑private partnership model.

Who is involved: Sen. Thom Tillis (R‑NC), Sen. Alex Padilla (D‑CA), advocacy group ASANA Voices, and the National Institutes of Health.

Likely next: The bill will be referred to the Senate Health, Education, Labor, and Pensions Committee for markup, with possible hearings and a vote in the coming months.

Senators Thom Tillis (R‑NC) and Alex Padilla (D‑CA) have unveiled the HEART Act, which would establish the Heart Security Foundation as a congressionally chartered nonprofit operating under the National Institutes of Health. The initiative aims to pool federal, private and philanthropic resources to speed up research, prevention and early detection of heart disease, the nation’s leading cause of death. By anchoring the foundation within NIH, the bill leverages existing scientific infrastructure while seeking to broaden funding streams across sectors.

What's next — scenarios

Bipartisan Fast-Track (50%)

Health tech and pharma firms should prepare for accelerated public-private grant opportunities in early diagnostics by Q3.

Legislative Stagnation (35%)

Venture capital in cardiovascular startups will rely entirely on traditional NIH grants and private markets without newly pooled capital.

Expanded Scope Amendment (15%)

Medtech companies must adjust R&D pipelines to incorporate metabolic and diabetes tracking alongside cardiovascular metrics.

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